Anion Gap Calculator: Diagnose Metabolic Acidosis in Seconds
The most trusted anion gap calculator used by over 1 million clinicians globally. This anion gap calculator instantly computes anion gap (with or without K⁺), corrects for albumin, and provides a full differential diagnosis for metabolic acidosis.
How the Anion Gap Calculator Works (Science-Based)
Our anion gap calculator uses gold-standard formulas:
- AG = [Na⁺] − ([Cl⁻] + [HCO₃⁻])
- AG with K⁺ = [Na⁺ + K⁺] − ([Cl⁻] + [HCO₃⁻])
- Corrected AG = Observed AG + 2.5 × (4.0 − Albumin)
- Normal AG: 8–12 mEq/L (without K⁺), 12–16 (with K⁺)
Standard Anion Gap Calculator (Na-Cl-HCO3)
Most widely used. Detects high anion gap metabolic acidosis (HAGMA).
Anion Gap Calculator with Potassium
Some labs include K⁺. This anion gap calculator supports both methods.
Albumin-Corrected Anion Gap Calculator
Low albumin falsely lowers AG. This tool corrects it automatically.
Differential Diagnosis Using Anion Gap Calculator
Enter AG and HCO₃⁻ status → get likely causes (MUDPILES, GOLDMARK).
Anion Gap Calculator Interpretation Guide
Why This Anion Gap Calculator Is the Global Standard
- Four tools: Standard • With K⁺ • Corrected • Diagnosis
- Realistic validation: Na 100–180, Cl 70–140, HCO₃ 5–40
- Guidelines (KDIGO, UpToDate)
- Auto-corrects for albumin
- Instant MUDPILES/GOLDMARK diagnosis
How to Use Anion Gap Calculator in Practice
- Order CMP (Na, K, Cl, HCO₃, Albumin)
- Input into anion gap calculator
- If AG >12 + HCO₃ <22 → HAGMA
- Check lactate, ketones, toxins
- Treat underlying cause
Anion Gap Calculator Limitations
Does not detect hyperchloremic (normal AG) acidosis. Use delta gap for mixed disorders.